Technical Support: sfb1190-support@gwdg.de
Department of Medical Informatics
University Medical Center Göttingen
SFB 1190 - Imprint
View primary antibody
Basic data
| PID | umg-sfb1190-antibody-primary-0687 |
| EPIC PID | https://hdl.handle.net/21.11124/umg-sfb1190-antibody-primary-0687 |
| Research group | AG Rizzoli |
| Quality (mean) | no score (0.00) |
| Sharing level | Public |
Antibody data
| Antigen symbol | SNAP25 |
| Antibody Registry ID(s) | AB_887790 |
| Name | SNAP 25 |
| Alternative name | synaptosome-associated protein 25 |
| Lab ID | |
| Tag / Fluorophore | |
| Raised in | Rabbit |
| Reacts with | Human, Rat, Mouse, hamster, chicken, goldfish |
| Clone | |
| Isotype | |
| Clonality | polyclonal |
| Demasking | unknown |
| Antigen | Synthetic peptide corresponding to AA 192 to 206 from human SNAP25 |
| Crafted By | company |
| Company / Manufacturer | Synaptic Systems |
| Catalog no. | 111 002 |
| Lot no. | |
| Description | WB: 1 : 10000 (AP staining) IP: yes ICC: 1 : 500 IHC: 1 : 200 IHC-P/FFPE: 1 : 500 ELISA: yes (see remarks) |
| Localization | SNAP 25 (synaptosome-associated protein of 25 kDa) is a highly conserved protein anchored to thecytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP 25 is thetarget of Botulinum neurotoxin A and E which cleave off 9 and 26 amino acids, respectively, from theC-terminus. SNAP 25 is part of the exocytotic fusion complex (v-SNARE) of neurons where it assembles withsyntaxin 1 and synaptobrevin. It is abundantly localized on the neuronal plasmalemma and onrecycling vesicles including synaptic vesicles. It is also expressed in neuroendocrine cells. There aretwo splice-variants, SNAP 25A and 25B. |
| Storage instruction | |
| Receipt date | 2019-01-01 00:00:00 |
| Preparation date | 2019-03-04 00:00:00 |
| Created by | , |
| Last modified | Administrator, Administrator |
External links
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Linked publications
Newly produced synaptic vesicle proteins are preferentially used in synaptic transmission
Truckenbrodt S, Viplav A, Jähne S, Vogts A, Denker A, Wildhagen H, Fornasiero EF, Rizzoli SO
EMBO J 2018 : 10.15252/embj.201798044
